### Principles of sample size calculation - The EQUATOR Network

Principles of sample size calculation Aim – We wish to compare the outcome between the treatments and determine if there is a difference between them Typically approach for RCT sample size calculation – Choose the key (primary) outcome and base the calculation on it – Get a large enough sample size to have reassurance that we will be

- Published in: Indian Journal of Ophthalmology · 2010Authors: N J Gogtay